Osteogenic Differentiation of Dental Follicle Stem Cells

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Osteogenic Differentiation of Dental Follicle Stem Cells

BACKGROUND Stem cells are defined as clonogenic cells capable of self-renewal and multi-lineage differentiation. A population of these cells has been identified in human Dental Follicle (DF). Dental Follicle Stem Cells (DFSCs) were found in pediatric unerupted wisdom teeth and have been shown to differentiate, under particular conditions, into various cell types of the mesenchymal tissues. AI...

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The dexamethasone induced osteogenic differentiation of dental follicle cells.

Mesenchymal stem cells are excellent for in vitro studies about biological processes during the differentiation of osteogenic progenitor cells into mineralizing cells such as osteoblasts. Human dental follicle cells (DFCs) are dental mesenchymal stem cells and they can be isolated from third molar teeth. Because DFCs are the genuine progenitor cells of periodontal tissue cells, they have been u...

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Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells

The present study aimed to investigate the effect of Dickkopf-related protein 3 (DKK3) on osteogenic differentiation of rat dental follicle cells (DFCs). A PCR array analysis of Wnt pathway activation in DFCs identified genes dysregulated by mineral induction. Among them, DKK3expression levels were decreased, and further experiments were conducted to investigate its role in DFC osteogenesis. By...

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ژورنال

عنوان ژورنال: International Journal of Medical Sciences

سال: 2012

ISSN: 1449-1907

DOI: 10.7150/ijms.4583